Ron Goldberg

Adverse outcomes in drug-resistant TB with diabetes

Diabetes mellitus may lead to adverse outcomes in multidrug-resistant tuberculosis (MDR-TB) or DR-TB, according to systematic review and meta-analysis findings published in BMC Infectious Diseases.

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TB burden higher in vulnerable populations vs general populations

Asylum seekers, refugees, those with HIV, incarcerated individuals, and homeless individuals often had TB prevalence ratios greater than 25 vs the general population.

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Using inhaled corticosteroids in COPD increases TB, pneumonia rates

Patients who use inhaled corticosteroids (ICS) to treat chronic obstructive pulmonary disease (COPD) have higher rates of tuberculosis and pneumonia than those who do not use ICS, according to study findings published in the International Journal of Chronic Obstructive Pulmonary Disease.

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An estimated 35% of MDR-TB is extensively drug-resistant- or pre-XDR-TB

Among those with MDR-TB included in the meta-analysis, 27% showed resistance to fluoroquinolones and 11% showed resistance to second-line injectable drugs.

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Undernutrition linked to increased mortality in multidrug-resistant TB

Patients with multidrug-resistant tuberculosis with a body mass index of less than 18.5kg/m2 had a 2.8-times higher odds of death.

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Drug-resistant TB: Does moxifloxacin prolong QT interval?

Moxifloxacin, when used as part of a shorter treatment regimen for drug-resistant tuberculosis (DR-TB), appears not to increase the risk for prolonging the QT interval (ie, interval between heart contraction and relaxation — the Q through T waves seen on electrocardiogram). This was among study results recently published in the Journal of Clinical Tuberculosis and other Mycobacterial Diseases.

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Demographic, mycobacteriologic features in subclinical pulmonary TB

In high-income countries like Canada, patients with subclinical pulmonary tuberculosis (TB) are a heterogeneous group, accounting for one-fifth of all pulmonary TB culture-positive cases, according to findings published in Chest.

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