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Progression from infection to pulmonary TB follows distinct timeline

Researchers have uncovered a sequence of biological processes that occur in humans infected with the bacterium Mycobacterium tuberculosis as the infection progresses to pulmonary tuberculosis, according to new research published in PLOS Pathogens.

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Parasite protein could help inform new anti-TB strategies

Proteins produced by the parasite that causes toxoplasmosis may be involved in immune system processes that can help fight mycobacteria, according to a new study. The findings, published in PLOS Pathogens, suggest that these proteins could potentially play a role in new treatment strategies for tuberculosis.

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Multidrug-resistant TB appears less transmissible in households than drug-susceptible TB

Some strains of multidrug resistant tuberculosis (MDRTB) may have a lower fitness (be less capable of spreading) than drug-susceptible tuberculosis bacteria, according to a study published this week in PLOS Medicine. The study, conducted by Louis Grandjean of Imperial College London, and colleagues, compared new tuberculosis cases among household contacts of tuberculosis patients in South Lima and Callao, Peru to determine the relative fitness of MDRTB versus drug-susceptible tuberculosis.

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Scientists unveil secrets of important natural antibiotic

An international team of scientists has discovered how an important natural antibiotic called dermcidin, produced by our skin when we sweat, is a highly efficient tool to fight tuberculosis germs and other dangerous bugs.

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Whole genome sequencing better at tracing TB outbreaks than standard test

A new form of genetic testing of the bacteria that causes tuberculosis can provide better information on TB transmission and also trace TB outbreaks more accurately than the current standard test, according to a study from Germany published in this week's PLOS Medicine.

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Research reveals new drug target urgently needed for tuberculosis therapy

One third of the world is infected with the bacterium that causes tuberculosis (TB), a disease that is increasingly difficult to treat because of wide spread resistance to available drugs. Researchers from the Institute of Pharmacology and Structural Biology (CNRS, Université de Toulouse) in Toulouse (France) have identified a fresh target to develop new drugs for TB. The study, published in the Open Access journal PLOS Pathogens, shows why the target will be important in developing new TB treatments.

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Next generation vaccines: Eliminating the use of needles

Scientists at Royal Holloway, University of London have developed a pioneering new method of oral vaccination which could help boost immunity to tuberculosis (TB) and influenza, as well as prevent C. difficile for which there is currently no vaccine.

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Technology brings new life to the study of diseases in old bones

A study led by The University of Manchester has demonstrated that new technology that can analyse millions of gene sequences in a matter of seconds is an effective way to quickly and accurately identify diseases in skeletons.

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Frontal attack or stealth?

ScienceDaily (Feb. 27, 2012) — Why is it that Mycobacterium tuberculosis can cause tuberculosis with as little as 10 cells, whereas Vibrio cholerae requires the host to ingest up to tens of millions of cells to cause cholera? This is the question that two research teams, from the Pasteur Institute, in France, and the Instituto Gulbenkian de Ciencia and the University of Lisbon, in Portugal, answer in the latest issue of the journal PLoS Pathogens.

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