Caitlyn Stulpin

Systematic, test-guided TB treatment result in similar outcomes

Systematic treatment for tuberculosis was not superior to test-guided treatment in reducing mortality or invasive bacterial disease among immunosuppressed adults with HIV, according to findings in The New England Journal of Medicine.

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Latent TB infection associated with very high alcohol use among people with HIV

Compared with medium-level alcohol use, very high use correlated with latent tuberculosis infection among adults with HIV in Uganda, according to a cross-sectional study in Clinical Infectious Diseases.

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TB in women in Ethiopia associated with HIV infection and aging

Tuberculosis among pregnant women in Ethiopia independently correlated with HIV infection and increasing age, which suggests that young women in the country are continuously exposed to, and infected with, contagious TB, according to findings in Clinical Infectious Diseases.

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TB recurrence increases by nearly ninefold between episodes 2 and 5

Rates of tuberculosis recurrence increased by almost ninefold between episode 2 and 5 regardless of HIV status, according to a study assessing recurrent tuberculosis in Cape Town, South Africa, over a 13-year period.

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Low BMI, presence of diabetes affect TB treatment outcomes

Low BMI was significantly associated with an increased risk for adverse treatment outcomes in patients with tuberculosis, although comorbid diabetes resulted in “unexpectedly” better outcomes for these patients, according to a study in a South Indian cohort.

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Lack of clinical response to antibiotics ‘strong predictor’ of TB among adults with HIV

Failure to respond to antibiotics may serve as a strong indicator of tuberculosis among people living with HIV who have symptoms of the disease, according to findings published in Open Forum Infectious Diseases.

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Bedaquiline-based treatment associated with favorable outcomes in patients with MDR-TB

Bedaquiline-based regimens for treating patients with multidrug-resistant tuberculosis, MDR-TB, were associated with favorable outcomes and a lower rate of acquired drug resistance compared with delamanid-based regimens, according to a study conducted in the country of Georgia.

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BCG vaccination associated with lower prevalence of LTBI in adults

Bacille Calmette-Guérin, or BCG, vaccination is associated with a lower prevalence of latent tuberculosis infection in adult TB contacts and could protect against Mycobacterium tuberculosis infection, according to results published in Journal of Infectious Diseases.

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Rifampin-resistant TB associated with HIV, increased mortality

An analysis of 17 years of national surveillance data showed that all forms of rifampin resistance in patients with tuberculosis were positively associated with HIV infection, delayed culture conversion and increased mortality, researchers reported.

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US: Active case-finding shows HIV/TB coinfection prevalent in country of Georgia

An active case-finding strategy uncovered a “very high prevalence” of tuberculosis coinfection among newly diagnosed HIV-infected patients in the country of Georgia, according to a recent study.

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