Caitlyn Stulpin

In shadow of COVID-19, TB vaccine research enters new era

In less than a year, scientists were able to develop several efficacious vaccines against COVID-19.

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Self-administered 3HP associated with high treatment completion for latent TB

Self-administered isoniazid-rifapentine taken once weekly — a regimen called 3HP — was associated with higher treatment completion rates for latent tuberculosis infection compared with daily rifampin, according to a study.

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Systematic, test-guided TB treatment result in similar outcomes

Systematic treatment for tuberculosis was not superior to test-guided treatment in reducing mortality or invasive bacterial disease among immunosuppressed adults with HIV, according to findings in The New England Journal of Medicine.

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Latent TB infection associated with very high alcohol use among people with HIV

Compared with medium-level alcohol use, very high use correlated with latent tuberculosis infection among adults with HIV in Uganda, according to a cross-sectional study in Clinical Infectious Diseases.

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TB in women in Ethiopia associated with HIV infection and aging

Tuberculosis among pregnant women in Ethiopia independently correlated with HIV infection and increasing age, which suggests that young women in the country are continuously exposed to, and infected with, contagious TB, according to findings in Clinical Infectious Diseases.

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TB recurrence increases by nearly ninefold between episodes 2 and 5

Rates of tuberculosis recurrence increased by almost ninefold between episode 2 and 5 regardless of HIV status, according to a study assessing recurrent tuberculosis in Cape Town, South Africa, over a 13-year period.

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Low BMI, presence of diabetes affect TB treatment outcomes

Low BMI was significantly associated with an increased risk for adverse treatment outcomes in patients with tuberculosis, although comorbid diabetes resulted in “unexpectedly” better outcomes for these patients, according to a study in a South Indian cohort.

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Lack of clinical response to antibiotics ‘strong predictor’ of TB among adults with HIV

Failure to respond to antibiotics may serve as a strong indicator of tuberculosis among people living with HIV who have symptoms of the disease, according to findings published in Open Forum Infectious Diseases.

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Bedaquiline-based treatment associated with favorable outcomes in patients with MDR-TB

Bedaquiline-based regimens for treating patients with multidrug-resistant tuberculosis, MDR-TB, were associated with favorable outcomes and a lower rate of acquired drug resistance compared with delamanid-based regimens, according to a study conducted in the country of Georgia.

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BCG vaccination associated with lower prevalence of LTBI in adults

Bacille Calmette-Guérin, or BCG, vaccination is associated with a lower prevalence of latent tuberculosis infection in adult TB contacts and could protect against Mycobacterium tuberculosis infection, according to results published in Journal of Infectious Diseases.

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