Trinity College Dublin

Fresh hope for improving treatments for deadly lung disease

Tuberculosis (TB) is still one of the biggest infectious killers in the world. Multiple drug resistant (MDR) TB has become a global health emergency, an emerging European crisis, and an important Irish public health concern. Many challenges remain in the global fight against this disease including a clinical need for effective treatments against MDR-TB.

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TB in Irish prisons: New study recommends increased testing

Investigators from Trinity College Dublin, the Irish Mycobacteria Reference Laboratory, St James’s Hospital,  and the Department of Public Health HSE East believe tuberculosis (TB) care in Irish Prisons should be supported, considering the findings of their study which is published in the International Journal of Tuberculosis and Lung Disease.

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New research shows how immune response to TB differs in babies

The immune response to tuberculosis (TB) differs in adults and newborn babies due to the way immune cells use energy to kick into gear in a bid to kill the bacteria. This fresh discovery – just published in leading journal, Frontiers in Immunology – offers hope for improving treatments for what remains a deadly disease.

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Scientists find that binding iron improves the effect of the anti-TB drug bedaquiline

Although TB killed nearly as many people as COVID-19 (approx. 1.8 million) in 2020, it did not receive as much media and public attention. The pandemic has proven that transmissible infection is indeed a global issue. TB remains a serious public health concern in Ireland, particularly with the presence of multi-drug resistant types and the numbers of complex cases here continuing to rise, with cases numbering over 300 annually.

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How blocking iron drives the lung immune system to control infection

Although COVID-19 commands the headlines today, tuberculosis (TB) remains the biggest infection killer in the world and multiple drug resistant TB, which does not respond to regular antibiotics, continues to be a major threat to global health.

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Scientists discover how TB puts the brakes on our immune engines

Scientists from Trinity College Dublin have discovered both how TB puts the brakes on our immune engines and how we can kick-start those engines back into gear -- providing hope that improved treatment options could soon be on the horizon.

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Can an exhausted lung cell of a smoker fight bacterial infection?

Researchers at Trinity College Dublin have discovered how lung cell exhaustion affects a patient’s ability to fight diseases.

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Scientists discover how vitamin A drives the lung immune system to control TB

Scientists at Trinity College Dublin and St James’s Hospital, Dublin, have discovered how vitamin A drives the lung immune system to deal with tuberculosis (TB). The findings have just been published in a top respiratory journal, the American Journal of Respiratory Cell and Molecular Biology.

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Scientists discover how TB hijacks the immune system

Scientists have unlocked a key element in understanding how human lungs fight tuberculosis (TB). They hope their research findings, which were published in the international peer reviewed journal Immunity, will help pave the way towards new treatment approaches for TB, particularly in an era of increasing antibiotic resistance to TB.

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New understanding of TB could lead to personalised treatments

Tuberculosis (TB) used to kill one in seven people around the world before the advent of antibiotics. However the increasing prevalence of multi-drug resistant TB means that doctors are running out of options in trying to combat this bacterium.

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