New research has shown that Mycobacterium tuberculosis (MTB) controls its growth by modifying its DNA.
A new study explores how tuberculosis (TB) controls its own growth on a molecular level. The research team behind the study, led by the University of Surrey and the University of Oxford, propose that this identifies a new target for antibiotics against TB.
TB is usually caused by the MTB bacterium, and it grows very slowly, allowing it to cause infections that may last a lifetime. One-quarter of the world's population may be infected with TB without knowing they have it, and it is estimated that TB causes around 1.3 million deaths each year.
In a study published in Nature, the research team reveal that the newly discovered DNA modification system involves two enzymes, DarT and DarG, that reversibly modify chromosomal DNA to create a 'switch' that coordinates bacterial replication. By interfering with the DarT/DarG system, it becomes massively toxic to the bacterium and represents the target for a new class of antibiotics.
Graham Stewart, Professor of Molecular Bacteriology at the University of Surrey and lead author of the study, said: "Before Covid-19, tuberculosis killed more people each year than any other infectious disease, and it will regain its infamy once the pandemic subsides.
"Tuberculosis is a global health emergency and current antibiotics are becoming ineffective. This study describes a genuinely new piece of DNA biology that could be targeted by new antibiotics."
More information: Marion Schuller et al, Molecular basis for DarT ADP-ribosylation of a DNA base, Nature (2021). DOI: 10.1038/s41586-021-03825-4
Source: University of Surrey