Items tagged with Diagnostics
Bruker announces improved assay for TB diagnostics in novel Liquid Array™ format for improved multiplexing (post)
-- Expanded FluoroType™ MTBDR 2.0 Liquid Array molecular assay with CE-IVD mark provides highly differentiated tuberculosis (TB) detection and antibiotic resistance testing
-- Novel FluoroCycler™ XT PCR system with CE-IVD mark enables new Liquid Array format
Diagnosing TB: a Cochrane Special Collection (post)
Tuberculosis (TB) causes more deaths globally than any other infectious disease and is a top 10 cause of death worldwide. When it is detected early and effectively treated, TB is largely curable, but in 2017, around 1.6 million people died of tuberculosis, including 300,000 people living with HIV.[1] Early diagnosis of TB, including universal drug susceptibility testing and systematic screening of contacts and high-risk groups, is a pillar of the World Health Organization (WHO) "End TB" strategy.
Stanford researchers develop a simple new blood test for TB (post)
While tuberculosis testing is now routine, standard tests don’t work for kids, people with HIV/AIDS and others who struggle to cough anything up from their lungs. A Stanford team is developing a new test to fill the gap.
Xpert testing to find TB in people with advanced HIV at diagnosis saves lives, study finds (post)
In sub-Saharan Africa where the odds of dying within a year of starting treatment for HIV can still hover close to one-in-10, diagnosing and treating TB — a curable disease that remains the leading cause of death for people with the virus — at the point of HIV testing offers a life-saving opportunity to improve patients’ chances. That makes accurate, point of care testing all the more urgently needed in places like in rural Malawi, where an X-ray to identify TB, and treatment for the disease based on symptoms, can be out of reach during the wait for laboratory test results.
QuantiFERON-TB Gold-Plus performance in children with confirmed TB (post)
Although the new interferon-gamma release assay QuantiFERON-TB Gold Plus® (QFT-Plus) had good sensitivity in children with pulmonary tuberculosis (TB) only, QFT-Plus had poor sensitivity in children with extra-pulmonary TB only, according to a study published in PLoS One. Further, findings indicated that positive QFT-Plus results may be associated with age, previous TB disease history, and TB-related chest radiography abnormalities.
Funding to discover and validate novel biomarkers, diagnostics for TB diagnosis (post)
NIAID recognizes a need for non-sputum-based tuberculosis (TB) diagnostics for use in HIV-1-infected and HIV-1-exposed uninfected children to improve and simplify rapid and decentralized diagnosis of TB disease. To support biomarker discovery and biomarker-based assay development, NIAID will fund R01 research projects through the new funding opportunity announcement (FOA) Advancing Biomarker Discovery and Novel Point-of-Care Diagnostics for Active TB Disease Detection in HIV-1 Infected and Exposed Children (R01, Clinical Trial Optional).
Harvard undergrad's AI model helps to predict TB resistance (post)
One of the greatest challenges in treating tuberculosis—the top infectious killer worldwide, according to the World Health Organization (WHO)—is the bacterium's ability to shapeshift rapidly and become resistant to multiple drugs. Identifying resistant strains quickly and choosing the right antibiotics to treat them remains difficult for several reasons, including the bacterium's propensity to grow slowly in the lab, which can delay drug-sensitivity test results by as much as six weeks after initial diagnosis.
New Roche test aids clinicians in accelerating TB diagnosis and treatment by detecting antimicrobial resistance within the world's leading cause of infectious disease deaths (post)
-- New tests on cobas 6800/8800 systems provide clinicians information to help speed treatment and reduce the spread of infection
-- Rising challenge of drug resistance compounds the tuberculosis global health crisis
-- Mycobacteria test menu allows detection of tuberculosis, drug resistant tuberculosis and nontuberculous mycobacteria infections from single patient sample
TB LAM test improves TB diagnosis in people with low CD4 counts (post)
Use of the TB LAM test in people with HIV with CD4 counts below 200 boosted the number of people diagnosed with tuberculosis (TB) by a third, an observational study in Malawi and Mozambique has found. Almost half of TB cases would have been missed if LAM had not been included in the diagnostic algorithm, showing that the test is useful in a far wider population than currently recommended.
Diagnostics are essential for universal health coverage to succeed (post)
Forty years ago, 134 countries pledged to assure “Health For All” by the year 2000. They failed to deliver on that pledge. Today, at least 400 million people have no access to basic medical care, and 40% of the world’s population lacks social security protection.
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